tert-butyl (2-iodophenyl)carbamate
N-BOC-2-IODOANILINE 97
CAS: 161117-84-6
Molecular Formula: C11H14INO2
tert-butyl (2-iodophenyl)carbamate - Names and Identifiers
| Name | N-BOC-2-IODOANILINE 97 |
| Synonyms | N-Boc 2-iodoaniline N-BOC-2-IODOANILINE 97 N-BOC-2-IODOANILINE 97 tert-butyl (2-iodophenyl)carbaMate tert-butyl (2-iodophenyl)carbamate Carbamic acid,N-(2-iodophenyl)-, 1,1-dimethylethyl ester |
| CAS | 161117-84-6 |
| InChI | InChI=1/C11H14INO2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8(9)12/h4-7H,1-3H3,(H,13,14) |
tert-butyl (2-iodophenyl)carbamate - Physico-chemical Properties
| Molecular Formula | C11H14INO2 |
| Molar Mass | 319.14 |
| Density | 1.277 g/mL at 25 °C (lit.) |
| Boling Point | 85-95 °C/0.5 mmHg (lit.) |
| Flash Point | 132.964°C |
| Vapor Presure | 0.001mmHg at 25°C |
| pKa | 13.08±0.70(Predicted) |
| Refractive Index | n20/D 1.5690(lit.) |
| Physical and Chemical Properties | WGK Germany:3 |
tert-butyl (2-iodophenyl)carbamate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3082 9/PG 3 |
| WGK Germany | 3 |
tert-butyl (2-iodophenyl)carbamate - Introduction
N-BOC-2-IODOANILINE 97 is an organic compound with the following properties:
1. Appearance: Colorless or white crystalline solid.
2. Solubility: soluble in polar organic solvents, such as ether and hydrochloric acid.
3. Melting Point: about 60-63 ° C.
4. Molecular formula: C13H16INO2.
5. Molecular weight: 355.18g/mol.
N-BOC-2-IODOANILINE 97 has some important uses and applications in organic synthesis:
1. As an intermediate: It can be used as an intermediate for the synthesis of drugs, pesticides and bioactive molecules, and for the synthesis of complex organic compounds.
2. For amination reaction: N-BOC-2-IODOANILINE 97 can be used in amination reaction, iodine atom is replaced by amino group by reducing agent, and the corresponding N-Boc 2-aniline compound is obtained.
The method for preparing N-BOC-2-IODOANILINE 97 is as follows:
Dissolve 2-iodoaniline in hydrochloric acid, and then slowly add N-tert-butyl carbamate (Boc2O) solution Dropwise, and the reaction proceeds for several hours, after completion of the reaction, the inorganic salt by-product is removed from the solution and the desired N-BOC-2-IODOANILINE 97 product is obtained by concentration of the solvent and recrystallization.
Regarding safety information, N-BOC-2-IODOANILINE 97 is an organic matter, so it needs to be handled with appropriate laboratory safety measures. It can be irritating and corrosive to the skin, eyes and respiratory tract. Wear protective glasses, gloves and laboratory coats during operation. Inhalation or contact with skin should be avoided. If taken by mistake, seek medical attention immediately.
1. Appearance: Colorless or white crystalline solid.
2. Solubility: soluble in polar organic solvents, such as ether and hydrochloric acid.
3. Melting Point: about 60-63 ° C.
4. Molecular formula: C13H16INO2.
5. Molecular weight: 355.18g/mol.
N-BOC-2-IODOANILINE 97 has some important uses and applications in organic synthesis:
1. As an intermediate: It can be used as an intermediate for the synthesis of drugs, pesticides and bioactive molecules, and for the synthesis of complex organic compounds.
2. For amination reaction: N-BOC-2-IODOANILINE 97 can be used in amination reaction, iodine atom is replaced by amino group by reducing agent, and the corresponding N-Boc 2-aniline compound is obtained.
The method for preparing N-BOC-2-IODOANILINE 97 is as follows:
Dissolve 2-iodoaniline in hydrochloric acid, and then slowly add N-tert-butyl carbamate (Boc2O) solution Dropwise, and the reaction proceeds for several hours, after completion of the reaction, the inorganic salt by-product is removed from the solution and the desired N-BOC-2-IODOANILINE 97 product is obtained by concentration of the solvent and recrystallization.
Regarding safety information, N-BOC-2-IODOANILINE 97 is an organic matter, so it needs to be handled with appropriate laboratory safety measures. It can be irritating and corrosive to the skin, eyes and respiratory tract. Wear protective glasses, gloves and laboratory coats during operation. Inhalation or contact with skin should be avoided. If taken by mistake, seek medical attention immediately.
Last Update：2024-04-09 20:49:11
